Nightlife involving alcohol and other drug use, sexual behaviour and music and dancing go back millennia. Today going out and having fun, or to use the more colloquial term «partying», is one of the main leisure activities, for young people, in our society. During the last decades, the growth of night-time economies has expanded the opportunities for leisure activities but also the challenges for developing appropriate and effective prevention and harm reduction interventions in such settings. Nightlife can be seen as a trendsetter, not only in cultural and social terms but as a place of pleasure, ecstasy and excess, for which the use of substance plays a role, for many partygoers. For the City of Zurich, nightlife is an important cultural and economic factor. Every weekend more than 70’000 people are partying, in more than 160 bars and clubs, a high concentration for a city of 400’000 residents. Since over twenty years the Street Parade, with around 1 million visitors, the biggest rave in the world takes place in Zurich. In the mid 90’s, as XTC use increased, Zurich’s health department became aware of the specific health challenges of the Nightlife culture. Starting with an information campaign related to the use of XTC, targeting party goers, followed by the mobile Drug Checking service in 2001, the Safer Clubbing approaches 2004, the Drug Information Centre in 2006, the establishment of the Bar & Club commission 2011 and the building up of a night-major-council in 2015. Zurich’s integrated nightlife approach based on bottom-up processes and on cooperation between the night time industry and the public sector can be seen as best practice example to address the challenges of an attractive nightlife culture. Both speakers, Alexander Bücheli and Luca Rey are members of Zurich’s nightlife council. Alexander as managing director of the Bar & Club commission Zurich will present the goals of nightlife lobbying and the particular interests on a night council. Luca will present the activities of the council itself, the results but also the difficulties related to the chosen structure!